Studies on the resorption of experimental amyloidosis.

-The resorption of experimental murine amyloidosis induced by Freund's adjuvant was studied over a period of 45 weeks. Three weeks after cessation of the injections splenic amyloid was found in 56-4 per cent of the animals and hepatic amyloid in 10-3 per cent of the animals. Thereafter the incidence of amyloid decreased steadily by the 20th week but splenic amyloid was still present in 14*3 per cent of the animals after 45 weeks. Resorption of hepatic amyloid paralleled that of the splenic amyloid. Renal amyloidosis was not striking and did not increase during the resorption of splenic amyloid. The morphological picture encountered during resorption included alteration in the specific staining qualities ofthe amyloid in the later stages, an increase in the number of giant cells, lymphoid hyperplasia and infiltration of amyloid by histiocytes and polymorphonuclear leucocytes. The significance of these histological findings in relation to the process of resorption is discussed. No spontaneous amyloidosis was found.